IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/2018

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
MUC1 is a scaffold for selectin ligands in the human uterus
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1 Department of Biological Sciences, University of Delaware, Newark, DE 19716
2 Center for Women’s Medicine, Greenville Hospital System, Greenville, South Carolina 29617
3 Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA
Front. Biosci. (Landmark Ed) 2006, 11(3), 2903–2908; https://doi.org/10.2741/2018
Published: 1 September 2006
Abstract

MUC1 is a large, transmembrane mucin glycoprotein abundantly expressed at the apical surface of uterine epithelia in all species examined to date. Loss of MUC1 at the time of embryo implantation occurs in many species; however, this does not appear to be the case in humans. Recent studies indicate that human blastocysts express L-selectin at their external surfaces raising the possibility that selectin ligands expressed at the apical surface of the uterine epithelium support early stages of blastocyst attachment. In the current study, we have used a panel of antibodies specific for selectin ligands to determine if MUC1 functions as a scaffold for these carbohydrate motifs in fertile women. The results demonstrate that MUC1 carries selectin ligands throughout the secretory phase of the menstrual cycle, including the mid-secretory (receptive) phase. Consequently, MUC1 represents a potential ligand for selectins expressed by human blastocysts.

Keywords
MUC1
selectin ligand
endometrium
embryo implantation
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