IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/1980

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Epigallocatechin gallate, the main ingredient of green tea induces apoptosis in breast cancer cells
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1 Oncology Department of the First Hospital affiliated to Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Academic Editor:Changping Zou
Front. Biosci. (Landmark Ed) 2006, 11(3), 2428–2433; https://doi.org/10.2741/1980
Published: 1 September 2006
(This article belongs to the Special Issue Cancer chemoprevention - 1)
Abstract

Green tea has been suggested for prevention of cancers. In this study, the effect of the main constituent of green tea, epigallocatechin gallate (EGCG), on apoptosis of breast cancer cells was examined. EGCG induced apoptosis in T-47D cells through caspase cascade and the cells were detained at the G1 phase. The rate of apoptosis and activity of caspase-3 induced by EGCG was time and dose dependent. These findings suggest that EGCG might be useful in treatment and/or prevention of breast cancer by inducing apoptosis.

Keywords
Green tea
Apoptosis
Cell cycle
Caspase-3
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