IMR Press / FBL / Volume 11 / Issue 2 / DOI: 10.2741/1889

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Dendritic cells and CD4+CD25+ T regulatory cells: crosstalk between two professionals in immunity versus tolerance

Show Less
1 Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Heath, 30, Bethesda, MD 20892, USA

Academic Editor: Masoud Manjili

Front. Biosci. (Landmark Ed) 2006, 11(2), 1360–1370; https://doi.org/10.2741/1889
Published: 1 May 2006
(This article belongs to the Special Issue Gene regulation and signal transduction in CD4)
Abstract

Dendritic cells (DCs) are professional antigen presenting cells (APCs). CD4+CD25+ T regulatory cells (T regs) are recognized as professional regulatory cells. DCs not only initiate T cell immunity by uptake, processing and presentation of specific antigens, but also induce immune tolerance by deletion of T cells and/or induction of regulatory T cells. CD4+CD25+ T regs maintain immune tolerance by suppressing the function of CD4+ and CD8+ T cells, B cells, macrophages, DCs and NK cells. It would be inconceivable that the delicate balance between immunity and tolerance could be kept impeccable without the crosstalk between DCs and CD4+CD25+ T regs. This review focuses on the recent development in our understanding of DCs and CD4+CD25+ T regs in immune tolerance, with transforming growth factor-beta (TGF-β) serving as a potential link between these two professionals.

Keywords
DCs
CD4+ CD25+ Treg
TGF-β
Foxp3
Cytokine
IL-6
IL-10
Anergy
indoleamine 2
3- dioxygenase
CTLA-4
GITR
Review
Share
Back to top