IMR Press / FBL / Volume 11 / Issue 2 / DOI: 10.2741/1877

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The current epidemiology of cutaneous malignant melanoma
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1 Department of Internal Medicine, Cancer Treatment and Research Center, University of New Mexico, Albuquerque, NM 87131, USA

Academic Editor: Suzie Chen

Front. Biosci. (Landmark Ed) 2006, 11(2), 1244–1254; https://doi.org/10.2741/1877
Published: 1 May 2006
(This article belongs to the Special Issue Recent advances in melanoma)
Abstract

As a background for understanding the increased incidence of melanoma, relevant information focuses on incidence, morality, environmental factors, host factors, and genetic factors. Incidence has increased dramatically; however, it is not clear to what extent changes in behavior, in the environment, or in early detection are involved. The major environmental factor, ultraviolet radiation exposure, shows surprisingly modest risks for developing melanoma, approximately 1.7-fold, and so focus is turning to interactions of exposure with host factors, including genetic factors. The major host factors associated with the development of melanoma include skin type and numbers of nevi (as well as atypical nevi). Genetic factors associated with familial melanoma have been well described and new attention, not yet validated, is being paid to low penetrant genes and their polymorphisms.

Keywords
Melanoma incidence
Melanoma Mortality
Ultraviolet Radiation
Suntan Parlors
Genetic Epidemiology
Review
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