IMR Press / FBL / Volume 11 / Issue 2 / DOI: 10.2741/1874

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Using inbred mouse strains to identify genes for complex diseases
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1 Department of Preventive Medicine, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-907, USA
2 The Gonda Department of Cell and Molecular Biology, University of Southern California, Los Angeles, CA, USA
3 Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
4 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679
Front. Biosci. (Landmark Ed) 2006, 11(2), 1216–1226;
Published: 1 May 2006

In recent years, genetic studies in humans have identified a handful of genes that are associated with common disorders, but our understanding of such diseases at the genetic level remains relatively rudimentary. The use of mice to dissect the complex genetic etiology of common disorders offers a viable alternative to human studies since experimental parameters, such as environmental influences, breeding scheme, and detailed phenotyping can be controlled. This review focuses on the utility of mouse genetics for identification of complex disease genes. Atherosclerosis is used as a representative example, followed by an overview for the prospects of successful gene discovery in the future.

Inbred Mice
Complex Diseases
Gene Mapping
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