IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1842

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mechanisms of X-chromosome inactivation
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1 Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Academic Editor:Douglas Ruden
Front. Biosci. (Landmark Ed) 2006, 11(1), 852–866; https://doi.org/10.2741/1842
Published: 1 January 2006
(This article belongs to the Special Issue Epigenetic effects during development and disease launch)
Abstract

Mammalian X-chromosome inactivation is an impressive example of epigenetic gene regulation, whereby the majority of genes on the ~ 160 Mb X chromosome are silenced in a strictly cis-limited fashion. In this review we will discuss the important players involved in the silencing process. The process is initiated by transcription and cis-localization of the non-coding XIST RNA, which then recruits many of the epigenetic features generally associated with heterochromatin, including histone modifications, histone variants and DNA methylation.

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