IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1840

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Platelet-leukocyte aggregates and derived microparticles in inflammation, vascular remodelling and thrombosis
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1 I NSERM IFR63-EA 3470 Faculty of Medicine RTH Laennec, Lyon, France
2 Thrombosis Research Institute, London, UK
Academic Editor:Arthur Chu
Front. Biosci. (Landmark Ed) 2006, 11(1), 830–837; https://doi.org/10.2741/1840
Published: 1 January 2006
(This article belongs to the Special Issue Blood coagulation, inflammation, and thrombosis)
Abstract

As a result of vascular injury, activated platelets will rapidly interact with circulating platelets, via membrane glycoprotein complex alphaIIbbeta3 (GPIIb-IIIa) and fibrinogen, to form a thrombus or a plug preventing fatal bleeding. In addition, platelets interacting with ruptured atherosclerotic plaques or with the surface of diseased vessels can aggregate and induce ischemia that prevents blood flow. However, increasing evidence has also shown that circulating platelets interact with leukocytes and endothelial cells, via specific adhesion molecules, in inflammation, vascular remodelling and thrombosis. The aim of this chapter is to present the importance of cell-cell interactions involving platelets and leukocytes in events related to inflammation, coagulation, vascular remodelling and thrombosis. A key adhesion molecule implicated in platelet interaction with leukocytes is P-selectin, also known as CD62P. It is present on activated platelets and endothelial cells, and its counterpart on leukocytes is known as P-selectin glycoprotein ligand-1 (PSGL-1). A critical co-factor leading to leukocyte activation in platelet-monocyte aggregate formation is the presence of a chemokine known as RANTES. It acts in concert with platelet P-selectin and PSGL-1 in monocyte stimulation.

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