IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1833

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia
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1 Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Japan
2 Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, the University of Tokyo
3 Department of Neurosurgery, Gifu University School of Medicine, Japan
4 Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Japan
Academic Editor:Cesario Borlongan
Front. Biosci. (Landmark Ed) 2006, 11(1), 753–759; https://doi.org/10.2741/1833
Published: 1 January 2006
(This article belongs to the Special Issue Gene therapy for stroke)
Abstract

VEGF and HGF are pleiotropic factors that regulate cell growth, cell motility, and morphogenesis of various types of cells. The receptors of these growth factors are expressed in neurons and endothelial cells, and are identified as neurotrophic, neuroprotective, and angiogenic factors. Indeed, gene therapy using viral vectors encoding the VEGF or HGF gene has been reported to be effective for preventing the expansion of ischemic injury. However, the safety issue of viral vectors is a major problem in clinical application. To overcome this problem, we have developed an HVJ-based non-viral vector, which achieves high-efficiency transfection rates of viral vectors with the safety of liposomes. This review discusses the feasibility of gene therapy using an HVJ-based non-viral vector containing the VEGF or HGF gene for cerebral ischemia.

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