IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1832

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

New animal models to study the role of tyrosinase in normal retinal development
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1 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia (CNB-CSIC), Campus de Cantoblanco, C/ Darwin 3, 28049 Madrid, Spain
2 Current address: Department of Genetics, St. Jude Children Research Hospital, 332 N. Lauderdale, 38103 Memphis, TN, USA
Academic Editor:Vicente Andres
Front. Biosci. (Landmark Ed) 2006, 11(1), 743–752;
Published: 1 January 2006

Albino animals display a hypopigmented phenotype associated with several visual abnormalities, including rod photoreceptor cell deficits, abnormal patterns of connections between the eye and the brain and a general underdevelopment of central retina. Oculocutaneous albinism type I, a common form of albinism, is caused by mutations in the tyrosinase gene. In mice, the albino phenotype can be corrected by functional tyrosinase transgenes. Tyrosinase transgenic animals not only show normal pigmentation but the correction of all visual abnormalities associated with albinism, confirming a role of tyrosinase, a key enzyme in melanin biosynthesis, in normal retinal development. Here, we will discuss recent work carried out with new tyrosinase transgenic mouse models, to further analyse the role of tyrosinase in retinal development. We will first report a transgenic model with inducible tyrosinase expression that has been used to address the regulated activation of this gene and its associated effects on the development of the visual system. Second, we will comment on an interesting yeast artificial chromosome (YAC) –tyrosinase transgene, lacking important regulatory elements, that has highlighted the significance of local interactions between the retinal pigment epithelium (RPE) and developing neural retina.

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