IMR Press / FBL / Volume 11 / Issue 1 / DOI: 10.2741/1781

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Changes in laminin isoforms associated with brain tumor invasion and angiogenesis
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1 Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California
2 Ophthalmology Research Laboratories, Cedars-Sinai Medical Center, Los Angeles, California
Academic Editor:Homer Black
Front. Biosci. (Landmark Ed) 2006, 11(1), 81–88; https://doi.org/10.2741/1781
Published: 1 January 2006
(This article belongs to the Special Issue Photocarcinogenesis)
Abstract

Laminins are the major constituents of blood vessel basement membranes (BMs). Each laminin is a trimer consisting of three assembled polypeptide chains, α, β and γ. More than 15 laminin isoforms are known to date and the expression of specific isoforms may change in certain pathological conditions. Here we show that during progression of glial tumors laminin-9 (α4β2γ1) is switched to laminin-8 (α4β2γ1), which is dramatically increased in glial brain tumors. Laminin-8 overproduction by glial tumor cells facilitates spread of glioma. Brain tumors with laminin-8 overexpression recur faster after standard treatment and patients have shorter survival time. Laminin-8 may be thus used as a predictor of tumor recurrence, patient survival and as a potential molecular target for glioma therapy.

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