IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1770

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Regulation of NK cell activation by stimulatory and inhibitory receptors in tumor escape from innate immunity
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1 Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China
2 Institute of Immunopharmacology and Immunotherapy, School of pharmaceutical Sciences, Shandong University, Jinan, Shandong 250021, China
3 Institute of Basic Sciences, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China
Front. Biosci. (Landmark Ed) 2005, 10(3), 3132–3142;
Published: 1 September 2005

Recent years have witnessed our major progresses in understanding the membrane-bound receptors on NK cells. Although functional studies of ligands for these NK cell receptors provide good opportunities to study roles of NK cells in anti-tumor and anti-virus immunosurveillance, little was known about how these ligands expression were modulated under physiological and pathological conditions. Several recognition models have been proposed to explain such an issue, which include "missing-self", "induced-self" and "modified-self" recognition model. Here stimulatory immunoreceptor mediated NK cell activation will be reviewed, and possible recognition mechanism by which NK cells operate during interaction with target cells will be discussed in details. Tumor escape from NK cell-mediated immunosurveillance will also be further addressed.

NK cells
stimulatory immunoreceptors
cellular stress
heat shock protein
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