IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1748

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Stromal responses in human primary melanoma of the skin
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1 Department of Pathology, Radboud University Nijmegen Medical Center, PO box 9101, 6500 HB Nijmegen, The Netherlands

Academic Editor: Suzie Chen

Front. Biosci. (Landmark Ed) 2005, 10(3), 2922–2931;
Published: 1 September 2005
(This article belongs to the Special Issue Recent advances in melanoma)

Tumour development and progression has long been considered as the consequence of an imbalance between apoptosis and proliferation of transformed cells. However, whereas genetic aberrations leading to the activation of oncogenes and/or loss of tumour suppressor genes are crucial for the transformation towards aberrant cell growth, progression towards a full blown malignancy requires a dynamic interaction between tumour cells and the environment in which they thrive. Over the recent years, it has become evident that the (early) inflammatory and angiogenic response, and remodelling of the extracellular proteins are key factors in creating a microenvironment that sustains tumour growth and metastasis. The host response towards cutaneous melanoma has received relatively little attention, most likely because the majority of these tumours develop without evoking a strong stromal response as can be observed in, e.g., carcinomas. This review discusses potential critical modulators of melanoma growth: turn-over of the most abundant extracellular matrix protein in skin (i.e. type I collagen), the early inflammatory response and angiogenesis.

Type I collagen
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