IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1744

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Biology of Kaposi's sarcoma-associated herpesvirus
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1 Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA

Academic Editor: Shohreh Amini

Front. Biosci. (Landmark Ed) 2005, 10(3), 2882–2891; https://doi.org/10.2741/1744
Published: 1 September 2005
(This article belongs to the Special Issue AIDS-related malignant diseases)
Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8) is a newly identified herpesvirus. KSHV is an important pathogen capable of causing disease that affects all age groups worldwide. KSHV is etiologically associated with all forms of Kaposi's sarcoma (KS), body cavity lymphomas, and multicentric Castleman disease (MCD). The use of highly active antiretroviral therapy (HAART) since 1996 has markedly reduced the prevalence of KS in western countries, but because 99% of the 40 million patients with AIDS in the world cannot afford HAART, KSHV pathogenesis is still a very common problem. In this chapter, we delineate some of the latest findings about KSHV infection and pathogenesis.

Keywords
KSHV
HHV-8
Raf
VEGF
Endocytosis
Virus Entry
Review
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