IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1737

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Virus signaling and apoptosis in the central nervous system infection
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1 Calspan-University at Buffalo Research Center, Inc, Washington, DC 20036, USA

Academic Editor: Laure Aurelian

Front. Biosci. (Landmark Ed) 2005, 10(3), 2804–2819; https://doi.org/10.2741/1737
Published: 1 September 2005
Abstract

Viruses target the central nervous system (CNS) incidentally, due to complications of systemic infection, or specifically, by ascending via the axons of peripheral and cranial nerves. In the CNS, viruses cause acute disease (viz. encephalitis), latent infections or neurodegenerative pathology. Causation of acute disease or immune-mediated pathology, and virus involvement in the etiology of chronic neurodegenerative diseases depends, at least in part, on the ability to commander signaling pathways. Better understanding of these virus-host cell interactions will help identify molecular targets for the development of improved therapeutic strategies.

Keywords
Virus
Infection
Signaling Cascades
Cell Death
Apoptosis
Nervous System
CNS
Encephalitis
Neurodegeneration
Review
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