IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1732

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Inflammation-dependent thrombosis
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1 Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, MI 48109-0654, USA
2 Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor, MI

Academic Editor: Arthur Chu

Front. Biosci. (Landmark Ed) 2005, 10(3), 2750–2757;
Published: 1 September 2005
(This article belongs to the Special Issue Blood coagulation, inflammation, and thrombosis)

Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and pro-inflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.

Vascular Disease
Inflammatory Mediators
Tissue Factor
Adhesion Molecules
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