IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1694

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cardenolide and bufadienolide ligands of the sodium pump. How they work together in NaCl sensitive hypertension
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1 Laboratory of Cardiovascular Science, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA

Academic Editor: Joseph Shapiro

Front. Biosci. (Landmark Ed) 2005, 10(3), 2250–2256; https://doi.org/10.2741/1694
Published: 1 September 2005
(This article belongs to the Special Issue Regulation and function of NaK-ATPase in health and disease)
Abstract

For the past 50 years biomedical scientists have been in quest of an unidentified factor (hormone) that elevates blood pressure and regulates renal sodium transport, i.e., natriuretic hormone. Recent discoveries have led to the identification of such factors which are present in humans, rodents and amphibians, and which, in a complex manner, interact with each other and with the other regulatory systems. In experimental NaCl sensitive hypertension brain endogenous ouabain, via activation of renin-angiotensin system and of sympathetic nervous system, stimulates adrenocortical production of marinobufagenin, a natriuretic and a vasoconstrictor. The combined effects of these endogenous factors may account for the classical properties attributed by Dahl, deWardener and others to the hypothetical "natriuretic hormone".

Keywords
Na+
K+
Exchange ATPase
Antagonists
Inhibitors
Ouabain
Bufadienolides
Marinobufagenin
Renin
Angiotensin
Aldosterone System
Sodium
Diet
Hypertension
Review
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