IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1662

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

An interference-free implantable glucose microbiosensor based on use of a polymeric analyte regulating membrane
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1 Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669
Front. Biosci. (Landmark Ed) 2005, 10(2), 1797–1801;
Published: 1 May 2005

An implantable glucose microbiosensor that utilizes an electrodeposited redox polymer/glucose oxidase (GOX) sensing membrane and a highly hydrophilic poly (4-vinyl pyridine-co-acrylic acid) (PVP-PAC) overcoating as an analyte-regulating membrane has been developed. A gold microelectrode was electrodeposited with the redox polymer/GOX composite sensing membrane. Two polymers, a hydrophobic poly (4-vinyl pyridine) (PVP) and a hydrophilic PVP-PAC were investigated as possible analyte-regulating membranes. Each was mounted on the sensing layer via chemical cross-linking with poly(ethylene glycol) diglycidyl ether (PEGDGE). High current sensitivities of ∼220 nA/mM glucose were obtained in the presence of PVP-PAC. In the case of PVP, much lower sensitivities of ∼30 nA/mM were observed. However, only the biosensor with PVP-PAC showed excellent selectivity to glucose against interferants like oxygen and ascorbic acid (AA). The dynamic range is from 0 to 30 mM. The response time in amperometric measurements was less than 10 sec. Clinical trials showed good correlation between the readings of the subcutaneously implanted biosensor and blood sugar levels.

Redox Polymer
Glucose Oxidase
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