IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1659

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Epidermal growth factor receptor: is a novel therapeutic target for pancreatic cancer?
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1 Cancer Research Unit, Department of Veterans Affairs Medical Center, 4801 East Linwood Boulevard, Kansas City, MO 64128-2226, USA
2 Saint Luke’s Hospital and University of Missouri, Kansas City, MO

Academic Editor: Sushanta K. Banerjee

Front. Biosci. (Landmark Ed) 2005, 10(2), 1763–1767; https://doi.org/10.2741/1659
Published: 1 May 2005
(This article belongs to the Special Issue Growth factors and cancer)
Abstract

Expression of epidermal growth factor receptors (EGFR) is exaggerated in pancreatic adenocarcinoma and activation of EGFR appears to have an important role in the growth and differentiation of this and in other tumors. Therefore, blockade or inactivation of EGFR by monoclonal antibodies or by tyrosine kinase inhibitors has significant potential as an effective anti-cancer therapy. One of the very recent significant developments in the field of molecular biology involves the use of antisense of EGFR or EGFR gene silencing in pancreatic cancer cells as a potential targeted therapy for patients with pancreatic adenocarcinoma.

Keywords
Pancreas
Tyrosine Kinase Inhibitors
EGF
EGFR
Cancer
Treatment
Review
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