IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1642

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The role of the tumor microenvironment in hematological malignancies and implication for therapy
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1 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA

Academic Editor: Bin Ren

Front. Biosci. (Landmark Ed) 2005, 10(2), 1581–1596; https://doi.org/10.2741/1642
Published: 1 May 2005
(This article belongs to the Special Issue Tumor growth and metastasis: molecular signaling and therapy)
Abstract

The tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion, and metastasis by providing survival signals and a sanctuary site for tumor cells, by secretion of growth factors, pro-angiogenesis factors and direct adhesion molecule interactions. Our knowledge of microenvironment is only now beginning to unfold. In this review, the morphological and molecular characteristics of microenvironment in various hematological malignancies including acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome, lymphoma, chronic lymphocytic leukemia, and multiple myeloma are summarized and the molecular mechanisms of microenvironment contributing to leukemogenesis are elucidated. We also aim to discuss the encouraging preclinical and clinical trials for treatment of hematological malignancies by targeting the tumor microenvironment. Further understanding of the signal transduction pathways between tumor cells and microenvironment will lead to the development of novel targeted therapeutic agents and more effective combination of current drugs for fighting hematological malignancies.

Keywords
Tumor Microenvironment
Hematological Malignancies
Leukemia
Multiple Myeloma
Angiogenesis
Novel Therapy
Review
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