IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1639

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Recent progress in the CYP51 research focusing on its unique evolutionary and functional characteristics as a diversozyme P450
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1 Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo, Japan

Academic Editor: Norio Kagawa

Front. Biosci. (Landmark Ed) 2005, 10(2), 1546–1557;
Published: 1 May 2005
(This article belongs to the Special Issue Gene regulation and structure-function of P450 Cold stress response)

CYP51 (sterol 14-demethylase P450) is a family of P450 species having the same function in distinct kingdoms, which makes CYP51 a unique and important enzyme family for the discussion of evolution and diversification of P450. Although CYP51 was named to the P450 originally discovered in yeast and fungi, today, we know that members of CYP51 family exist ubiquitously in animals, plants, fishes, lower eukaryotes such as slime mold, and a part of bacteria. In this review, I describe following subjects: 1) CYP51 as a model family for understanding of diversification of P450, 2) the structure and function relationships of CYP51s.

Sterol 14-demethylation
P450 evolution
P450 diversification
Structure and function
Cytochrome P450 Review
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