IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1614

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system
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1 Department of Pharmacology and Toxicology, Queen's University Kingston, Ontario, Canada

Academic Editor: Sharron Francis

Front. Biosci. (Landmark Ed) 2005, 10(2), 1221–1228; https://doi.org/10.2741/1614
Published: 1 May 2005
Abstract

Numerous pharmacological and physiological agents acting via either cAMP- or cGMP-mediated impact the activities of cells of the cardiovascular system. While most define cAMP and cGMP signaling systems as separate and independent, recent advances in our understanding of cyclic nucleotide signaling, and more specifically, of the roles which cyclic nucleotide phosphodiesterases (PDEs) play in these events, have altered this view. In this short chapter, I will review the data identifying expression of several PDEs in cells of the cardiovascular system. In addition, I will review the data that identify PDEs as enzymes capable of allowing integration between cAMP and cGMP signaling in cells, and propose that cAMP and cGMP signaling systems can represent parallel and interdependent signaling systems. Moreover, I will propose that cGMP-mediated effects on the activities of variants of the Phosphodiesterase 2 (PDE2), PDE3 and PDE5 families may act to coordinate linkage between cAMP and cGMP signaling in these cells.

Keywords
cAMP
cGMP
Phosphodiesterases
Vascular Smooth Muscles
Vascular Endothelial Cells
Cardiomyocytes
Platelets
Singaling
Review
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