IMR Press / FBL / Volume 10 / Issue 1 / DOI: 10.2741/1590

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Multi-scale methodology: a key to deciphering systems biology
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1 State Key Laboratory of Bioreactor Engineering, National Engineer Research Center for Biotechnology, Department of Biochemical Engineering, East China University of Science and Technology, Shanghai 200237, China PR
Front. Biosci. (Landmark Ed) 2005, 10(1), 961–965;
Published: 1 January 2005

Presently, it is widely accepted complex systems couldn't be comprehended by studying parts in isolation without examining integrative and emergent properties, and system-level understanding thus has become the focus in biological science. However, it should also be noted that common systematic analysis was restricted to large-scale analysis at a certain level, while the facts that the nature of complex systems is their multi-scale structures was usually neglected or ignored. Therefore, this paper described a multi-scale methodology to investigate the nature of biological complexity and prospected this methodology could lead to a promising revolution in current system-level understanding and the integration of molecular biology databases.

Multiscale Methodology
Systems Biology
Complex Systems
Biological Networks
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