IMR Press / FBE / Volume 9 / Issue 2 / DOI: 10.2741/E805

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Current status of a unique vaccine preventing pregnancy

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1 Talwar Research Foundation, New Delhi, India
2 National Institute for Research in Reproductive Health, Mumbai, India
3 Indian Council of Medical Research, New Delhi, India
4 Department of Zoology, University of Rajasthan, Jaipur, India

*Author to whom correspondence should be addressed.

Academic Editors: Pradyumna Kumar Mishra, Radhey Shyam Sharma, Nirmal Kumar Lohiya, Siamak Tabibzadeh

Front. Biosci. (Elite Ed) 2017, 9(2), 321–332; https://doi.org/10.2741/E805
Published: 1 June 2017
(This article belongs to the Special Issue Reproductive biomedicine: from basics to translational outcome)
Abstract

The ability of a vaccine linking beta hCG to a carrier to generate antibodies against hCG, its reversibility and safety was established by Phase I clinical trials conducted in India, Finland, Sweden, Chile and Brazil. Employing a hetero-species dimer (beta hCG-αoLH) linked to tetanus toxoid further improved the immunogenicity of the vaccine. Phase II clinical trials showed that anti-hCG titres above 50 ng/ml prevented pregnancy of sexually active fertile women without derangement of ovulation and menstrual regularity. On decline of antibodies, women conceived again to give birth to normal progeny. A genetically engineered vaccine consisting of beta hCG linked to B subunit of heat labile enterotoxin of E. coli has been made. It is expressed as DNA as well as protein. Priming with DNA followed by protein version of the vaccine generates very high titres against hCG in mice. Extensive toxicology studies in 2 species of rodents, and marmosets have shown complete safety of the vaccine. The vaccine is cleared for Clinical trials by the National Review committee on Genetic Manipulation and Drugs Controller General of India.

Keywords
Contraception
Fertility control
Human chorionic gonadotropin
hCG
Review
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