IMR Press / FBE / Volume 9 / Issue 2 / DOI: 10.2741/E802

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Effect of ancestry on interleukin-10 haplotypes in chronic periodontitis

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1 Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil
2 Health Sciences Institute, Federal University of Para, Belém, PA, Brazil
3 Human Cytogenetics Laboratory, Federal University of Pará, Belém, PA, Brazil
4 Oncology Research Center, Federal University of Pará, Belém, PA, Brazil

*Author to whom correspondence should be addressed.

Academic Editors: Andrea Ribeiro-dos-Santos, Fabiano Cordeiro Moreira

Front. Biosci. (Elite Ed) 2017, 9(2), 276–285; https://doi.org/10.2741/E802
Published: 1 June 2017
(This article belongs to the Special Issue Clinical applications of epigenetics)
Abstract

Chronic periodontitis is caused by an inflammatory reaction of the periodontal tissues and alveolar bone. This inflammation is caused by periodontopathic bacteria located in the subgingival biofilm, resulting in inflammatory reactions that may lead to loss of attachment. This tissue destruction is a consequence of host immune and inflammatory responses to specific periodontal pathogens and their metabolic products. Cytokines modulate the immune response, altering its efficiency in the competition against pathogens and increasing periodontal susceptibility. This study investigated genetic polymorphisms in Interleukin 10 (A-1082G, C-819T and C-592A) in 205 individuals from an admixed Brazilian population. A significantly increased risk of developing chronic periodontitis was observed in individuals with low IL-10 production and Amerindian ancestry. These results suggest that the polymorphisms A-1082G, C-819T, and C-592A, which are associated with ancestry, are involved in the susceptibility to the development of chronic periodontitis in an admixed northern Brazilian population.

Keywords
Periodontal disease
Cytokine
Polymorphism
Cytokine
Molecular Gene
Immunity
Inflammation
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