IMR Press / FBE / Volume 9 / Issue 2 / DOI: 10.2741/E798

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer

Show Less
1 Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview drive, SW, Atlanta-30310, USA
2 Department of Obstetrics and Gynecology, Morehouse School of Medicine, 720 Westview drive, SW, Atlanta-30310, USA

*Author to whom correspondence should be addressed.

Academic Editor: Indrajit Chowdhury

Front. Biosci. (Elite Ed) 2017, 9(2), 235–245; https://doi.org/10.2741/E798
Published: 1 March 2017
(This article belongs to the Special Issue Recent progress in reproductive biology)
Abstract

Docetaxel is the most commonly used chemotherapeutic agent to target androgen signaling in metastatic prostate cancer (PCa); however, prolonged treatment with docetaxel results in drug-resistant cancer cells. Combination therapies have the potential of increasing the effectiveness of drug treatment as well as decreasing the side effects. Curcumin is a nontoxic organic compound with multifaceted chemopreventive potential. In this study, we evaluated whether curcumin can reinforce the effect of docetaxel on PCa cells. The PCa cell lines DU145 and PC3 were treated with curcumin and docetaxel alone or in combination. After completion of the treatment cell proliferation and the expression of pro-survival and anti-apoptotic markers and the signaling molecules were analyzed. The combined treatment of curcumin and docetaxel inhibited the proliferation and induced apoptosis significantly higher than the curcumin and docetaxel-treated group alone. Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2. These results suggest that curcumin can be a potential therapeutic contender in enhancing the efficacy of docetaxel in PCa treatment.

Keywords
Curcumin
Prostate Cancer
Apoptosis
Docetaxel
EGFR
PI3K
Phospho-AKT
NF-kB
p53
COX-2
Share
Back to top