IMR Press / FBE / Volume 9 / Issue 2 / DOI: 10.2741/E797

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Potential of redox therapies in neurodegenerative disorders

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1 Department of Physical Medicine, Medical University of Lodz, Hallera Square, 1, Lodz, Poland
2 Neurorehabilitation Ward, III General Hospital in Lodz, Milionowa 14, Lodz, Poland
3 Department of Chemistry and Clinical Biochemistry, Medical University of Lodz, Hallera Square 1, Lodz, Poland
4 Department of Pathology, Faculty of Health Sciences, Jan Kochanowski Memorial University of Kielce, Kielce, Poland
5 Ophthalmology Clinic Boni Frates Lodziensis, Lodz, Poland

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2017, 9(2), 214–234; https://doi.org/10.2741/E797
Published: 1 March 2017
Abstract

Recently significant advances have been made to understand the pathophysiological mechanisms of neurodegenerative disorders to provide real therapeutic benefits. There is evidence that persistent inflammation and oxidative stress are the crucial factors of ongoing cell damage in neurodegenerative complex etiology. The variety of reactive oxygen and nitrogen species are the cause of both axonal and neuronal destruction, which is pathological hallmark of neurodegeneration. Therefore, the reduction of oxidative stress is currently one of the main neuroprotective strategies. The World Health Organization (WHO) estimates that, by 2040, neurodegenerative diseases will be the main cause of death in industrialized countries ahead of the cancers. The redox therapeutic approch can target: degnerative component, inflammatory/autoimmune component and neurodegenerative component. Redox therapy should not be applied uniformly, and must be develop to target specific mechanisms. This review focus on the main antitoxidative therapies that are used in many countries as a supplements or even as a standart treatment. Aditionally, clinical synmptoms of most common neurodegenerative disordes and central nervous system structures involved in oxidative/nitrosative stress are showed.

Keywords
Neurodegeneration
Redox Therapy
Oxidative Stress
Review
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