IMR Press / FBE / Volume 9 / Issue 2 / DOI: 10.2741/E795

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Biphasic organo-bioceramic fibrous composite as a biomimetic extracellular matrix for bone tissue regeneratio

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1 Cancer Biology Research and Training Program, Department of Biological Sciences
2 Biomedical Engineering, Alabama State University, Montgomery, AL 36104, USA
3 Physical Sciences, Alabama State University, Montgomery, AL 36104, USA
4 Department of Material Science and Engineering, University of Alabama, Birmingham, AL USA

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2017, 9(2), 192–203;
Published: 1 March 2017

In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the scaffold by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscope (SEM) and assessed its biocompatibility. PCL/HA composite is superior as a scaffold compared to PCL alone. Furthermore, increasing HA content (5-10%) was more efficacious in supporting cell-scaffold attachment, expression of ECM molecules and proliferation. These results suggest that PCL/HA is useful as a scaffold for tissue regeneration.

PCL/HA scaffolds
Cell proliferation
ECM cell adhesion molecules
Bone tissue engineering
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