IMR Press / FBE / Volume 9 / Issue 1 / DOI: 10.2741/E794

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Associations of Alzheimer’s disease with macular degeneration

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1 Centre of Memory Disturbances, Section of Neurology, University Hospital of Perugia, Perugia, Italy
2 Department of Surgery and Biomedical Science, University of Perugia Ospedale S. Maria della Misericordia, Perugia, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Christian Saleh

Front. Biosci. (Elite Ed) 2017, 9(1), 174–191; https://doi.org/10.2741/E794
Published: 1 January 2017
(This article belongs to the Special Issue The polyhedral aspects of dementia)
Abstract

There is growing evidence of epidemiological, genetic, molecular and clinical links between Alzheimer’s disease (AD) and age-related macular degeneration (AMD). Major interest in the relationship between AD and AMD has derived from the evidence that beta-amyloid, the main component of senile plaques, the hallmark of AD, is also an important component of drusen, the hallmark of AMD. This finding has a great potential in the present era of anti-amyloid agents for the treatment of AD. The connection between AD and AMD is also supported by the evidence that the two diseases share other pathophysiological factors, such as oxidative stress and neuroinflammation. Accordingly, a few clinical trials have evaluated the efficacy of antioxidants on visual and cognitive performance in patients presenting both disorders. In this review, we summarize the pathophysiological and clinical evidence of the relationship between these two age-related disorders. Considering the increasing prevalence of both conditions along with the aging of the population, further investigations of this important issue are highly needed.

Keywords
Alzheimer’s Disease
Age-Related Macular Degeneration
Beta Amyloid
Drusen
Review
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