IMR Press / FBE / Volume 9 / Issue 1 / DOI: 10.2741/E788

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

ROS mediated pro-apoptotic effects of Tinospora cordifolia on breast cancer cells

Show Less
1 Molecular Cell Biology Lab, Department of Biochemistry, King George’s Medical University, Lucknow 226 003, UP, India
2 Department of Chemistry, Integral University, Lucknow 226 026, U.P., India
3 Division of Endocrinology, Central Drug Research Institute, Lucknow 226 031, U.P., India

*Author to whom correspondence should be addressed.

Academic Editor: Saheem Ahmad

Front. Biosci. (Elite Ed) 2017, 9(1), 89–101; https://doi.org/10.2741/E788
Published: 1 January 2017
(This article belongs to the Special Issue Biotechnological advancements in free radical biology and medicine)
Abstract

The inevitable development of chemoresistance and unmanageable side effects are the major therapeutic challenges in management of breast cancer imposing an urgent need for identification of novel therapeutic agents. In the present investigation, we report anti-proliferative activity of chloroform fraction of Tinospora cordifolia (TcCF), an Ayurvedic medicinal plant, on breast cancer cells. We found that TcCF inhibited growth of breast cancer cells, MDA-MB-231 and MCF-7. More interestingly, we observed TcCF treatment increased intra-cellular ROS levels, altered expression of pro and anti-apoptotic genes, decreased colony formation ability and induced apoptosis in breast cancer cells. We also found that inhibition of ROS abrogated TcCF induced apoptosis in breast cancer cells, emphasizing the role ROS in TcCF induced breast cancer cell death. Furthermore, we identified the presence of pharmacologically active compounds like rutin and quercetin which account for the anti-cancer property of TcCF against breast cancer cells. These data show TcCF is a promising anti-cancer agent against breast cancer cells.

Keywords
Tinospora cordifolia
Breast Cancer
ROS
Apoptosis
Phytochemicals
HPLC
Share
Back to top