IMR Press / FBE / Volume 9 / Issue 1 / DOI: 10.2741/E786

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Phytochemicals in the treatment of ovarian cancer

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1 Department of Zoology, University of Lucknow, Lucknow, 226007, India

*Author to whom correspondence should be addressed.

Academic Editor: Saheem Ahmad

Front. Biosci. (Elite Ed) 2017, 9(1), 67–75; https://doi.org/10.2741/E786
Published: 1 January 2017
(This article belongs to the Special Issue Biotechnological advancements in free radical biology and medicine)
Abstract

Ovarian cancer ranks 5th among the most common gynecologic cancers and causes the highest mortality in females. Here, we discuss the role of a group of natural products that are being used in treatment and prevention of a host of cancers including ovarian cancer. Some plants and nutraceuticals and their polyphenolic constituents such as flavones, flavonoids, and antioxidants have shown cytotoxic effects on cancer cells both in vitro and in vivo. While phytochemicals do not harm normal cells, they have been found to be cytotoxic to cancer cells by virtue of inhibition of proliferation and/or induction of apoptosis, making them ideal in cancer therapeutics or as adjunct to conventional treatment regimens.

Keywords
Phytochemcials
Ovarian Carcinoma
Polyphenols
Antioxidants
Apoptosis
Review
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