IMR Press / FBE / Volume 9 / Issue 1 / DOI: 10.2741/E783

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Novel biogenic synthesis of silver nanoparticles and their therapeutic potential

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1 Molecular Microbiology Laboratory, Biotechnology Department, Indian Institute of Technology, Roorkee 247667, Uttarakhand, India
2 Sapience Bioanalytical Research Lab, Bhopal 462021, Madhya Pradesh, India

*Author to whom correspondence should be addressed.

Academic Editor: Saheem Ahmad

Front. Biosci. (Elite Ed) 2017, 9(1), 33–43; https://doi.org/10.2741/E783
Published: 1 January 2017
(This article belongs to the Special Issue Biotechnological advancements in free radical biology and medicine)
Abstract

Here, we explored the medicinal uses of the novel biogenic silver nanoparticles of Pterospermum acerifolium (PaAgNPs) as a cost effective, eco-friendly, reducing and stabilizing compounds. The formation of PaAgNPs was confirmed by changing its color from colorless to yellowish brown, with maximum absorbance at 417 nm. FTIR spectrum of PaAgNPs suggested the presence of polycyclic compound similar to betulinic acid which plays as a capping agent and provided stability to PaAgNPs. FESEM and HRTEM images depicted the spherical shape of synthesized biogenic silver nanoparticles with an average particle size range of 10-20 nm. The EDX spectrum of the solution confirmed the presence of elemental silver signals. The crystalline nature of PaAgNPs was identified by XRD technique and its stability was recorded using Zeta potential analyzer. The antioxidant potential was assayed using diphenyl-β-picrylhydrazyl (DPPH). Maximum free radical scavenging action of PaAgNPs was 69.52% as compared to 63.53% for PALE. Using a model of carrageenan-induced paw edema in rats, PaAgNPs showed two-fold enhanced anti-inflammatory activity in vivo.

Keywords
PALE
PaAgNPs
Carrageenan
Paw Edema
DPPH
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