IMR Press / FBE / Volume 9 / Issue 1 / DOI: 10.2741/E781

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Mechanisms of protein aggregation and inhibition

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1 Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh - 200202, India
2 Molecular Biology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, Egypt

*Author to whom correspondence should be addressed.

Academic Editor: Kostas N. Priftis

Front. Biosci. (Elite Ed) 2017, 9(1), 1–20; https://doi.org/10.2741/E781
Published: 1 January 2017
(This article belongs to the Special Issue The wheezing illness in children)
Abstract

Protein and peptide aggregation raises keen interest due to their involvement in number of pathological conditions ranging from neurodegenerative disorders to systemic amyloidosis. Here, we have reviewed recent advances in mechanisms of aggregation, emerging technologies towards exploration, characterization of aggregate structures, detection at molecular level and the strategies to combat the phenomenon of aggregation both in cellular and in vitro conditions. In consistence, we have illustrated almost all factors that influence the protein aggregation both in vitro and in vivo environments. In addition, we have discussed a detailed journey of protein aggregation phenomenon that starts with very first events of protein aggregation. We had also described advancement in current scenarios, present aspects of fibril association to several life threatening disorders and current experimental strategies that are employed to oppose or reverse the amyloid formation.

Keywords
Protein Aggregation
Protein Misfolding
Amyloid
Review
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