IMR Press / FBE / Volume 8 / Issue 3 / DOI: 10.2741/E779

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


New insights into the bioactivity of peptides from probiotics

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1 Anti-Infective Research Lab., Department of Microbiology, Vidyasagar University, Midnapore 721102, WB, India
2 Department of Biotechnology, North Bengal University, Siliguri- 734013, Darjeeling, India
3 Department of Biology, Institute of Biological Sciences, Graduate Program in Genetics and Biotechnology, Federal University of Juiz de Fora, Juiz de Fora–MG, 36036-900, Brazil

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2016, 8(3), 450–459;
Published: 1 June 2016

Probiotics are unique bacteria that offer several therapeutic benefits to human beings when administered in optimum amounts. Probiotics are able to produce antimicrobial substances, which stimulate the body’s immune responses. Here, we review in detail the anti-infective peptides derived from probiotics and their potential immunomodulatory and anti-inflammatory activities, including a major role in cross-talk between probiotics and gut microbiota under adverse conditions. Insights from the engineered cell surface of probiotics may provide novel anti-infective therapy by heterologous expression of receptor peptides of bacterial toxins. It may be possible to use antigenic peptides from viral pathogens as live vaccines. Another possibility is to generate antiviral peptides that bind directly to virus particles, while some peptides exert anti-inflammatory and anticancer effects. Some extracellular polymeric substances might serve as anti-infective peptides. These avenues of treatment have remained largely unexplored to date, despite their potential in generating powerful anti-inflammatory and anti-infective products.

Anti-Infective Peptides
Heterologous Expression
Bacterial Surface Engineered
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