IMR Press / FBE / Volume 8 / Issue 3 / DOI: 10.2741/E777

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Genes associated with T helper 17 cell differentiation and function

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1 Izmir Institute of Technology, Department of Molecular Biology and Genetics, Molecular Immunology and Gene Regulation Laboratory, Urla, İzmir, 35430 Turkey

*Author to whom correspondence should be addressed.

Academic Editor: Munis Dundar

Front. Biosci. (Elite Ed) 2016, 8(3), 427–435; https://doi.org/10.2741/E777
Published: 1 June 2016
(This article belongs to the Special Issue Genes and genetics)
Abstract

Interleukin-17 (IL-17)-producing T helper cells (Th17 cells) constitute a lineage of CD4 effector T helper cells that is distinct from the Th1 and Th2 CD4 phenotypes. In humans, Th17 differentiation is induced in the presence of the cytokines IL-1 beta, IL-6 and TGF beta, whereas IL-23 maintains Th17 survival. Effector human Th17 cells express several cytokines and cell surface markers, including IL-17A, IL-17F, IL-22, IL-26, CCR6 and TNFα. Studies on human cells have revealed that the RORC2 transcription factor plays an effective role in Th17 differentiation. Th17 cells contribute to the host immune response by involving various pathologies, including rheumatoid arthritis, multiple sclerosis and Crohn’s disease. However, the full extent of their contribution to diseases is being investigated.The differentiation of Th17 cells is controlled by many transcription factors, including ROR gammat, IRF4, RUNX1, BATF, and STAT3. This review covers the general principles of CD4 T helper differentiation and the known transcription factors that play a role in the recently discovered Th17 cells.

Keywords
Th17
Th17 Differentiation
RORs
IRF4
BATF
RUNX1
FOXP3
STATs
Review
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