IMR Press / FBE / Volume 8 / Issue 2 / DOI: 10.2741/E768

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Optimizing microdialysis for deep brain stimulation

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1 Department of Neurology, Division of Functional Neurosurgery, Institute of Psychiatry, University of Sao Paulo School of Medicine, Rua Dr. Ovideo Pires de Campos, 785, Cerqueira Cesar, 01308-060, Sao Paulo, Brazil
2 Laboratory of Neuromodulation and Experimental Pain, Hospital Sirio-Libanes, Rua Professor Daher Cutait, 69, 01308060, Sao Paulo-SP, Brazil
3 Toronto Western Hospital, University of Toronto, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada
4 Centre for Addiction and Mental Health, 250 College St, Toronto, ON, M5T 1R8, Canada
5 Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02115, USA

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2016, 8(2), 299–310;
Published: 1 January 2016

Cerebral microdialysis is a chemical detection method capable of identifying and simultaneously sampling a wide range of substances in the micromilieu of the monitoring probe. The interstitial space of biological tissues and fluids is sampled through a thin fenestrated dialysis catheter inserted into the brain. The technique has been reported in patients with Parkinson’s disease. However, the procedure is not widely used by neurosurgeons, possibly owing to unclear indications and poor effective benefits, mostly secondary to significant pitfalls. In spite of the feasibility of microdialysis in humans, many factors can affect the quality of the process. Possible pitfalls include improperly designed probe, probe insertion effects, ineffective perfusion rate, issues to optimize stabilization period, and insufficient volume sample. This article reviews those key technical features necessary for performing microdialysis in humans during deep brain stimulation for Parkinson’s Disease.

Deep Brain Stimulation
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