IMR Press / FBE / Volume 8 / Issue 1 / DOI: 10.2741/E748

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Carcinogenicity, allergenicity, and lupus-inducibility of arylamines

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1 Department of Biological Sciences, University of Memphis, Memphis, Tennessee 38152

*Author to whom correspondence should be addressed.

Academic Editor: King-Thom Chung

Front. Biosci. (Elite Ed) 2016, 8(1), 29–39; https://doi.org/10.2741/E748
Published: 1 January 2016
(This article belongs to the Special Issue Arylamine induced carcinogenesis)
Abstract

Arylamines are widely used in food, drugs, and cosmetics as well as other industries. These chemicals are present ubiquitously in cigarette smoke, smoke emitted from cooking fume hoods as well as are generated by diverse industries. Arylamines can be generated by cleavage of azo dyes by intestinal and skin microbiota. Some arylamines are used as drugs while others are constituents of human metabolism. Many of the arylamines are mutagenic and carcinogenic. They are generally recognized as the major cause of human bladder cancer, but arylamines can induce cancers of other organs in humans and animals. Some arylamines are allergenic, causing lupus like syndrome, or other maladies. In view of their unbiquitious nature and the diseases they cause, arylamines are probably the most important chemicals causing health problems.

Keywords
Arylamine
Carcinogen
allergen
Aromatic amines Lupus Erthytomatosus
Review
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