IMR Press / FBE / Volume 8 / Issue 1 / DOI: 10.2741/756

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Diet and sex hormones regulate hepatic Synaptotagmin 1 mRNA in mice

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1 Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Instituto Investigacion Sanitaria de Aragon (IIS), Universidad de Zaragoza, Spain
2 Instituto de Investigacion Sanitaria de Aragon (IIS), Universidad de Zaragoza, Spain
3 Departamento de Produccion Animal, Escuela Politecnica Superior de Huesca, Spain
4 Departamento de Patologia Animal, Facultad de Veterinaria, Universidad de Zaragoza, Spain
5 CIBER de Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Spain

*Author to whom correspondence should be addressed.

Front. Biosci. (Elite Ed) 2016, 8(1), 129–142; https://doi.org/10.2741/756
Published: 1 January 2016
Abstract

The expression of Synaptotagmin 1 (Syt1) has been found to be associated with the lipid droplets in liver. Here, we studied the expression of Syt1 in Apoe-deficient mice receiving cholesterol, Western diet, squalene, and oleanolic acid. We also studied the influence of sex and impact of surgical castration. Dietary cholesterol increased hepatic Syt1 expression, an effect that was enhanced when cholesterol was combined with saturated fat present in a Western diet. This potentiation was modified by the administration of 10 mg/kg oleanolic acid or 1 g/kg squalene. Females fed chow or Western diet showed higher levels of hepatic Syt1 expression as compared to male mice on the same diet. Surgical castration of males did not modify the Syt1 expression; however, ovariectomy led to decreased levels. The data show that hepatic Syt1 expression is influenced by diet and hormonal milieu.

Keywords
Synaptotagmin 1
Cholesterol
Apolipoprotein E Deficient Mice
Squalene
High-Fat Diet
Syt1
sex
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