IMR Press / FBE / Volume 8 / Issue 1 / DOI: 10.2741/746

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Current unmet needs in renal transplantation: a review of challenges and therapeutics

Show Less
1 Amgen, Nephrology Therapeutic Area, Thousand Oaks, CA

*Author to whom correspondence should be addressed.

Academic Editors: Ogo Egbuna, Jean Francis

Front. Biosci. (Elite Ed) 2016, 8(1), 1–14; https://doi.org/10.2741/746
Published: 1 January 2016
Abstract

While has been considerable progress in the short-term outcomes following renal transplantation over the last several decades, minimal gains have been made with regards to long-term graft function and patient survival (1). The lack of long-term gains has been attributed to factors such as antibody mediated rejection (AMR), chronic allograft nephropathy (CAN), and toxicity to the allograft secondary to immunosuppression. Ischemia reperfusion injury (IRI) is also thought to contribute to poor long-term graft function, and its impact on patient and graft outcomes will likely expand with the increasing use of marginal kidneys secondary to organ shortages. While patient survival remains far below that of the general population, the causes of death have evolved in recent years with decreases in the rate of death from cardiovascular disease and infection, and increases secondary to malignancy (2), which are largely attributable to the potency of modern immunosuppression. As such, the development of novel therapies which can prevent delayed graft function (DGF), minimize AMR, while simultaneously reducing toxicity is vital to the improvement of long-term graft and patient outcomes.

Keywords
Transplantation
Delayed Graft Function
Post-Transplant Malignancy
Antibody-Mediated Rejection
Chronic Allograft Nephropathy
Transplant Glomerulopathy
Review
Share
Back to top