IMR Press / FBE / Volume 7 / Issue 3 / DOI: 10.2741/E739

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg
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1 Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy
2 Clinical Biochemistry, Department of Biomedical Science, G. D’Annunzio, University of Chieti, Italy
3 Department of Internal Medicine and Aging Science, University G. D’Annunzio, Chieti, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Giovanni Li Volti

Front. Biosci. (Elite Ed) 2015, 7(3), 417–422; https://doi.org/10.2741/E739
Published: 1 June 2015
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

Increased levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and low plasma level of L-arginine (L-ARG) are all conditions likely to decrease nitric oxide (NO) production. Aim of this study is to evaluate ADMA, SDMA, and L-ARG plasmatic levels before and after physical exercise in patients with coronary artery disease (CAD). We studied 30 patient with mean age 52 ± 4.5 years. After inclusion in the study, before the execution of physical exercise, heparinized blood sample was drawn from an indwelling arterial line for determination of ADMA, L-ARG and SDMA (baseline values). Subsequently a blood sample was drawn after the physical exercise. The mean plasma concentrations of ADMA (0.68 ± 0.06 vs 0.48 ± 0.05 µmol/L) and SDMA (0.45 ± 0.03 vs 0.30 ± 0.03 µmol/L) were significantly lower after physical exercise in comparison to baseline value, while L-ARG mean levels were increased (44.20 ± 10.5 vs 74.13 ± 11.2 µmol/L). Physical exercise has a beneficial effect by reducing plasmatic ADMA and SDMA levels, and increasing L-ARG substrate for endothelial NO.

Keywords
ADMA
SDMA L-arginine
Nitric Oxide
Coronary Artery Disease
Physical Exercise
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