IMR Press / FBE / Volume 7 / Issue 2 / DOI: 10.2741/E737

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Occurrence, uses, and carcinogenicity of arylamines
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1 Department of Biological Sciences, The University of Memphis, Memphis, TN 38152, U.S.A.

*Author to whom correspondence should be addressed.

Academic Editor: King-Thom Chung

Front. Biosci. (Elite Ed) 2015, 7(2), 367–393; https://doi.org/10.2741/E737
Published: 1 January 2015
(This article belongs to the Special Issue Arylamine induced carcinogenesis)
Abstract

Arylamines are chemically synthesized and contained in oxidants, epoxy polymers, explosives, fungicides, pesticides, colorants, polyurethanes, and are used in various chemical industries. Many arylamines are present in cigarette smoke, cooking fume hoods, foods, automobile exhaust, industrial sites, etc. Arylamines can be generated through azo reduction by intestinal, skin, and environmental microbes from widely used azo dyes; by reduction of the nitro-group containing polyhydrated hydrocarbons; or by release of burning nitrogen containing organic materials. Some medicines are arylamines. Some arylamines are essential constituents, or the result of abnormal metabolism of foods. Some arylamines are mutagenic or carcinogenic. Arylamines can also cause various diseases. Some arylamine are the major etiological agents of bladder tumors but may induce other types of cancers. The organ, tissue, and species specificity of the arylamine-inducing carcinogenesis may be determined by their availability, distribution, and the presence of metabolic activation/detoxicification enzymes of each organ or tissue of different species. The ubiquitous arylamines, therefore, pose serious hazards to human health and environment. This article will address the occurrence, uses, carcinogenicity, and other arylamines-induced diseases.

Keywords
Arylamines
Cancer
Carcinogenesis
Chemical induced cancer
Review
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