IMR Press / FBE / Volume 7 / Issue 2 / DOI: 10.2741/E732

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Andrographolide and analogues in cancer prevention
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1 Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar 470003, India
2 Vegetable Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Suwon 440706, Republic of Korea
3 Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 406840, Republic of Korea

*Author to whom correspondence should be addressed.

Academic Editors: Aditi Mehrotra, Surendra Kumar Trigun, Raj Kumar Koiri, Dharmendra Sharma

Front. Biosci. (Elite Ed) 2015, 7(2), 292–304; https://doi.org/10.2741/E732
Published: 1 January 2015
(This article belongs to the Special Issue Frontiers in modern biology)
Abstract

Andrographis paniculata is a medicinal plant traditionally used for treatment of cough and cold, fever, laryngitis, and several infectious diseases. Extracts of A. paniculata have shown versatile potency against various diseases including cancer. The active biomolecules of A. paniculata mainly are lactone and diterpene. Andrographolide and analogues have been widely used for prevention of different diseases. Andrographolides have shown potent antiinflammatory and anticancer activities. It showed potentials as chemopreventive agents by suppressing growth of cancer cells by inhibiting NF-κB, PI3K/AKT and other kinase pathways and by inducing apoptosis. Andrographolide induced both intrinsic and extrinsic apoptosis pathway in different cancer cells via expression of different anti-apoptotic protein like Bax, p53, and activated caspases. Andrographolide was successfully used as an antineoplastic drug in cancer chemotherapy. Andrographolide inhibited the growth of human breast, prostate, and hepatoma tumors. Andrographolide and analogues need to be subjected to further clinical and biomedical studies in cancer chemoprevention. Andrographolide could be potent anticancer agent when used in combination with other chemotherapeutic agents.

Keywords
Andrographis paniculata
Andrographolide
Anticancer
Antiinflammation
Apoptosis Induction
Cell Cycle Arrest
Cancer Prevention
Review
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