IMR Press / FBE / Volume 7 / Issue 2 / DOI: 10.2741/E728

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Understanding the functional discrepancy of Pim-1 in cancer

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1 Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman
2 Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman

*Author to whom correspondence should be addressed.

Academic Editor: Allal Ouhtit

Front. Biosci. (Elite Ed) 2015, 7(2), 239–247; https://doi.org/10.2741/E728
Published: 1 January 2015
(This article belongs to the Special Issue Oxidative stress and cardiovascular diseases)
Abstract

The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt’s lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

Keywords
Pim-1 Kinase
Prostate Cancer
CAMKs
Inhibitors
Review
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