Understanding the functional discrepancy of Pim-1 in cancer

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Review

Allal Ouhtit^1,*, Sukalp Muzumdar¹, Ishita Gupta¹, Somya Shanmuganathan¹, Yahya Tamimi²

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¹ Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman

² Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman

*Author to whom correspondence should be addressed.

Academic Editor: Allal Ouhtit

Front. Biosci. (Elite Ed) 2015, 7(2), 239–247; https://doi.org/10.2741/E728

Published: 1 January 2015

(This article belongs to the Special Issue Oxidative stress and cardiovascular diseases)

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Abstract

The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt’s lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

Keywords

Pim-1 Kinase

Prostate Cancer

CAMKs

Inhibitors

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Front. Biosci. (Elite Ed) Print ISSN 1945-0494 Electronic ISSN 1945-0508