IMR Press / FBE / Volume 7 / Issue 1 / DOI: 10.2741/E720

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle
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1 School of Pharmacy, Levine College of Health Sciences, Wingate University, Wingate, North Carolina 28174

*Author to whom correspondence should be addressed.

Academic Editor: Amie J. Dirks-Naylor

Front. Biosci. (Elite Ed) 2015, 7(1), 107–121; https://doi.org/10.2741/E720
Published: 1 January 2015
(This article belongs to the Special Issue Mechanisms of skeletal muscle dysfunction and preventative measures)
Abstract

Type 2 diabetes is a common metabolic disorder characterized by resistance to the actions of insulin to stimulate skeletal muscle glucose disposal. In light of the staggering financial/human cost of type 2 diabetes, there is considerable need for safe and effective agents that can be used to prevent and/or adjunctively treat the disease. Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population. The evidence also suggests that, when used adjunctively, these natural products are likely to help clinicians achieve optimal glycemic control, improve long-term prognosis, and/or minimize the need for insulin therapy in type 2 diabetics. More research, particularly well-designed, long-term human clinical trials, is certainly needed to accurately define the value and place of these supplements in diabetes prevention and management.

Keywords
Type 2 diabetes mellitus
Natural products
Dietary supplements
Skeletal muscle
Insulin resistance
Review
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