IMR Press / FBE / Volume 7 / Issue 1 / DOI: 10.2741/722

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Ischemia-reperfusion injury in kidney transplantation
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1 Section of Transplant Surgery, Washington University School of Medicine, St. Louis, MO
2 Department of Surgery, Washington University School of Medicine, St. Louis, MO

*Author to whom correspondence should be addressed.

Academic Editors: Ogo Egbuna, Jean Francis

Front. Biosci. (Elite Ed) 2015, 7(1), 134–154; https://doi.org/10.2741/722
Published: 1 January 2015
Abstract

Ischemia-reperfusion injury to the kidney is a complex pathophysiological process that has importance during transplantation as it affects graft function and survival. It starts with the physiological changes associated with the death of the donor, including the direct effects of hypoxia and metabolic stress. The injury continues through the organ procurement and preservation procedures. Upon reperfusion, the organ is then further damaged by a reactive inflammatory process which had been primed during the earlier injuries. Clinically, the damage from microvascular dysfunction and cytotoxic agents contributed by the immunologic response results in impaired graft function or graft loss. Recent advances in understanding the specific pathways involved in this injury have helped identify novel therapies. Nevertheless, ischemia-reperfusion injury continues to be a daunting problem even as these treatment strategies are being evaluated for clinical use.

Keywords
Ischemia-reperfusion injury
Kidney transplantation
Review
Delayed graft function
Hypoxia
Oxidative Stress
Endothelial dysfunction
Innate immunity
Review
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