IMR Press / FBE / Volume 6 / Issue 2 / DOI: 10.2741/E710

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Role of agmatine in neurodegenerative diseases and epilepsy
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1 Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
2 Departamento de Clinica Medica, Hospital Universitario, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
3 Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil

*Author to whom correspondence should be addressed.

Academic Editor: Antoni Camins

Front. Biosci. (Elite Ed) 2014, 6(2), 341–359; https://doi.org/10.2741/E710
Published: 1 June 2014
(This article belongs to the Special Issue Current advances in epilepsy and neurodegeneration)
Abstract

Agmatine, a cationic polyamine synthesized after decarboxylation of L-arginine by the enzyme arginine decarboxylase, is an endogenous neuromodulator that emerges as a potential agent to manage diverse central nervous system (CNS) disorders. Consistent with its neuromodulatory and neuroprotective properties, there is increasing number of preclinical studies demonstrating the beneficial effects of exogenous agmatine administration on depression, anxiety, hypoxic ischemia, nociception, morphine tolerance, memory, Parkinson's disease, Alzheimer`s disease, traumatic brain injury related alterations/disorders and epilepsy. The aim of this review is to summarize the knowledge about the effects of agmatine in CNS and point out its potential as new pharmacological treatment for diverse neurological and neurodegenerative diseases. Moreover, some molecular mechanisms underlying the neuroprotective effects of agmatine will be discussed.

Keywords
Agmatine
Depression
Neurodegenerative Disease
Neuroprotection
Epilepsy
Review
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