IMR Press / FBE / Volume 6 / Issue 2 / DOI: 10.2741/707

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Involvement of PARPs in cell death
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1 Istituto di Genetica Molecolare CNR, Pavia, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Maria Rosaria Faraone-Mennella

Front. Biosci. (Elite Ed) 2014, 6(2), 308–317; https://doi.org/10.2741/707
Published: 1 June 2014
(This article belongs to the Special Issue Involvement of PARPs in cell death)
Abstract

Poly(ADP-ribosylation), an NAD dependent reaction culminating in the formation of ADP-ribose monomers, and their following polymerization, is activated as an emergency process in crucial situations such as DNA damage and cellular stress; due to this crucial function, the modulation of poly(ADP-ribosylation) during cell death has been investigated. This review will describe the properties of poly(ADP-ribose) as a signalling molecule in different paradigms of cell death, i.e. apoptosis, parthanatos, necroptosis and autophagy.


Keywords
Apoptosis
Autophagy
Necroptosis
PARP
PAR
Parthanatos
Review
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