IMR Press / FBE / Volume 6 / Issue 1 / DOI: 10.2741/E695

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Polycystic ovary syndrome: current status and future perspective
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1 Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, West Virginia University School of Medicine, Health Sciences Center, Morgantown, WV 26506-9186, USA

*Author to whom correspondence should be addressed.

Academic Editor: Rajesh K. Naz

Front. Biosci. (Elite Ed) 2014, 6(1), 104–119; https://doi.org/10.2741/E695
Published: 1 January 2014
(This article belongs to the Special Issue Male reproductive medicine)
Abstract

Polycystic ovary syndrome (PCOS) is a widespread reproductive disorder that encompasses many associated health conditions and has an impact on various metabolic processes. PCOS is depicted by hyperandrogenism, polycystic ovaries, and anovulation. It increases the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. The etiology of the disease remains unclear, and the subjective phenotype makes a united diagnosis difficult among physicians. It seems to be a familial genetic syndrome caused by a combination of environmental and genetic factors. It can be linked with metabolic disorders in first-degree family members. PCOS is the cause of up to 30% of infertility in couples seeking treatment. Currently, there is no cure for PCOS. Despite the growing incidence of this syndrome, limited research has been done that encompasses the entirety of PCOS spectrum. In this review, the current status and possible future perspective will be discussed.

Keywords
Polycystic ovary syndrome
PCOS
Obesity
Insulin Resistance
Diabetes
Metformin
Review
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