IMR Press / FBE / Volume 5 / Issue 3 / DOI: 10.2741/E679

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Autophagy in epithelial homeostasis and defense

Show Less
1 Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand
2 Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria

*Author to whom correspondence should be addressed.

Academic Editor: Leopold Eckhart

Front. Biosci. (Elite Ed) 2013, 5(3), 1000–1010; https://doi.org/10.2741/E679
Published: 1 June 2013
(This article belongs to the Special Issue Skin barrier)
Abstract

Autophagy delivers protein aggregates, damaged organelles and intracellular microorganisms to the lysosome for degradation. The epidermis and other epithelia show significant levels of autophagy, however, the functions of autophagy in these tissues have remained elusive until recently. Here we review the experimental approaches for the investigation of autophagy in epithelia and discuss the roles of autophagy in epithelial cells with a focus on epidermal keratinocytes and thymic epithelial cells.

Keywords
Autophagy
Epidermis
Keratinocytes
Lysosome
Ultraviolet radiation
Stratum corneum
Antimicrobial Defense
Inflammation
Share
Back to top