IMR Press / FBE / Volume 5 / Issue 3 / DOI: 10.2741/E678

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Advances in studying phasic dopamine signaling in brain reward mechanisms

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1 Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, USA
2 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
3 Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill North Carolina, USA
4 Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill North Carolina, USA
5 Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

*Author to whom correspondence should be addressed.

Academic Editor: R. N. Addy

Front. Biosci. (Elite Ed) 2013, 5(3), 982–999; https://doi.org/10.2741/E678
Published: 1 June 2013
(This article belongs to the Special Issue Subsecond dopamine signaling in the mammalian brain)
Abstract

The last sixty years of research has provided extraordinary advances of our knowledge of the reward system. Since its discovery as a neurotransmitter by Carlsson and colleagues (1), dopamine (DA) has emerged as an important mediator of reward processing. As a result, a number of electrochemical techniques have been developed to measure DA in the brain. Together, these techniques have begun to elucidate the complex roles of tonic and phasic DA signaling in reward processing and addiction. In this review, we will first provide a guide for the most commonly used electrochemical methods for DA detection and describe their utility in furthering our knowledge about DA's role in reward and addiction. Second, we will review the value of common in vitro and in vivo preparations and describe their ability to address different types of questions. Last, we will review recent data that has provided new mechanistic insight of in vivo phasic DA signaling and its role in reward processing and reward-mediated behavior.

Keywords
Dopamine
Voltammetry
Striatum
Rewardrelated behavior
Psychostimulant
Reinforcement learning
Review
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