IMR Press / FBE / Volume 5 / Issue 3 / DOI: 10.2741/E675

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Silicon nanotweezers for biomechanical and bioelectrical assays

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1 LIMMS/CNRS-IIS, (UMI 2820) Center for International Research on Micromechatronics, CIRMM, Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba Meguro Ku Tokyo 153-8505, Japan

*Author to whom correspondence should be addressed.

Academic Editor: Hideyuki Arata

Front. Biosci. (Elite Ed) 2013, 5(3), 955–965; https://doi.org/10.2741/E675
Published: 1 June 2013
(This article belongs to the Special Issue Nano- micro- technologies for molecular biology)
Abstract

In modern life, technologies enabling detection of biological molecules at a low threshold, for health and ecological concerns, are in high demand. Directly interrogating the molecules is a promising direction to clarify the noisy response of conventional assays arising from simultaneous different reactions. Besides sophisticated biophysical instrument such as the atomic force microscope, this paper proposes silicon nanotweezers (SNT) as a new microsystem for molecular manipulation. SNT can trap molecules and sense their biomechanical and bioelectrical response in minute operations. In this review SNT characteristics are overviewed; their operation modes are illustrated by molecule and cell trapping, manipulation and characterization in air and in solution. As they are tiny and can be mass produced by highly parallel microsystem technology, SNT can be seen as a potential molecular and cellular probe for routine analysis and bio detection.

Keywords
Molecular manipulation
silicon nano tweezers
bio mechanical characterization
electrical characterization
DNA
Gelatin
cell compression
Pdnanodot
Review
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